Does 5-FU cause cardiotoxicity?

5-Fluorouracil (5-FU) is an antimetabolite chemotherapy used for a variety of solid tumors. It has the potential to cause a wide spectrum of cardiotoxicity, ranging from asymptomatic electrocardiographic changes to cardiomyopathy and subsequent cardiac failure.

Does 5-FU cause heart problems?

Cardiac side effects of the cytostatic agent 5-fluorouracil (5-FU) have an incidence of 1.2-7.6%. Potentially, arrhythmias, myocardial infarction and sudden cardiac death could occur. Life-threatening cardiotoxicity is rarely observed with a frequency <1%.

How can chemotherapy related cardiotoxicity be detected?

MRI remains the gold standard for evaluating LV function, but it is expensive. Troponins are effective biomarkers for the early detection of cardiotoxicity; they can detect drug-induced cardiotoxicity in the earliest phase, before any reduction in LVEF.

Can folfox cause heart problems?

The incidence of Takotsubo cardiomyopathy due to 5-fluorouracil based chemotherapeutic regimens like FOLFOX is not uncommon. It is also seen with platinum based chemotherapy. Most of these patients have reversible cardiotoxicity and the cardiac function recovers within a short period with supportive treatment.

How is cardiotoxicity treated?

The most common medications used for cardiotoxicity treatment include: Beta-blockers, which slow down a patient’s heart rate, lower a patient’s blood pressure and strengthen the heart muscle can reduce palpitations and arrhythmias, hypertension and heart failure.

Is cardiotoxicity reversible?

Type I cardiotoxicity is caused by cardiomyocyte death, either through necrosis or apoptosis, and as a result is not reversible. Type II cardiotoxicity is caused by cardiomyocyte dysfunction rather than cell death and therefore may be reversible.

When do 5-FU side effects start?

Hand-foot syndrome consists of swelling, redness, pain, and/or peeling of the skin on the palms of hands and/or soles of the feet. This is typically mild and starts approximately five to six weeks after beginning treatment. However, if more severe, this side effect may require dose reductions.

When do 5FU side effects start?

Is there a risk of cardiotoxicity with 5-FU?

A recent meta-analysis indicates that the incidence of symptomatic cardiotoxicity is 0–20% in patients treated with 5-FU and 3–35% in patients receiving capecitabine [ 10 ].

Is there cardiotoxicity of 5 Fu and capecitabine?

While 5-FU- and capecitabine-associated cardiotoxicity has been widely addressed in the US and European countries, the incidence and risk factors for such cardiotoxicity, to our knowledge, has never been prospectively investigated in Chinese patients.

Are there any side effects of 5 Fu?

A potential severe side effect of 5-FU is cardiotoxicity, which often presents with chest pain related to coronary vasospasm.

Why is there wide variation in Fu induced cardiotoxicity?

Such wide variation could be a reflection of different risk profiles in the study population and also the different administration schedules.