What is the normal range for Alpha-1 antitrypsin?
But a typical normal result will be between 75 and 150 milligrams per deciliter (mg/dL), depending on how the results were done. If your levels are too low, it may be a sign that you have 1 damaged gene, which means you are a carrier, or 2 damaged genes, which means you have AAT deficiency.
What does it mean if Alpha-1 antitrypsin is high?
In people with Alpha-1 (Alphas), large amounts of abnormal alpha-1 antitrypsin protein (AAT) are made in the liver; nearly 85 percent of this protein gets stuck in the liver. If the liver cannot break down the abnormal protein, the liver gradually gets damaged and scarred.
What is the clinical manifestation of alpha-1 antitrypsin?
People with alpha-1 antitrypsin deficiency usually develop the first signs and symptoms of lung disease between ages 25 and 50. The earliest symptoms are shortness of breath following mild activity, reduced ability to exercise, and wheezing.
Can you donate blood if you have alpha-1 antitrypsin deficiency?
Individuals with Alpha-1 may donate blood as long as they do not have emphysemaObstructive airway disease in which the walls of the alveoli (air sacs) are damaged or destroyed. More or liver disease and are not receiving augmentation therapy.
Does Alpha-1 cause fatty liver?
When a person has alpha-1 antitrypsin deficiency, the AAT in the liver is abnormal and not released from the liver at a normal rate. “It accumulates in the liver, where it’s toxic to the liver cell, and can ultimately lead to inflammation, cirrhosis, nonalcoholic fatty liver disease and liver cancer,” Dr. Donohue says.
What are the symptoms of alpha 1 antitrypsin deficiency?
Alpha-1 antitrypsin deficiency (AATD) can present as lung disease in adults and can be associated with liver disease in a small portion of affected children. In affected adults, the first symptoms of AATD are shortness of breath with mild activity, reduced ability to exercise and wheezing.
How does the alpha-1 antitrypsin Pi phenotype test work?
Alpha-1 antitrypsin PI type of phenotype test, which determines the type of AAT protein that a person has. Alpha-1 antitrypsin level test, which determines the amount of AAT in a person’s blood. Individuals who have symptoms that suggest AATD or who have a family history of AATD should consider being tested. What is the treatment for AATD?
Can a person with AATD produce alpha-1 antitripsin?
Individuals with AATD have one normal copy and one damaged copy, or they have two damaged copies. Most individuals who have one normal gene can produce enough alpha-1 antitripsin to live healthy lives, especially if they do not smoke.
How many copies of the alpha-1 antitripsin gene are there?
Most people have two normal copies of the alpha-1 antitrypsin gene. Individuals with AATD have one normal copy and one damaged copy, or they have two damaged copies. Most individuals who have one normal gene can produce enough alpha-1 antitripsin to live healthy lives, especially if they do not smoke.