Is desirudin available in the US?

Desirudin was approved for use in the United States in 2003 and has been used in limited numbers of patients. Current indications are limited to reduction of the risk of deep vein thrombosis and pulmonary embolization after elective hip replacement surgery.

What is desirudin used for?

Desirudin is used to prevent deep venous thrombosis, a condition in which harmful blood clots form in the blood vessels of the legs. These blood clots can travel to the lungs and can become lodged in the blood vessels of the lungs, causing a condition called pulmonary embolism.

What is Iprivask?

Iprivask® (desirudin for injection) is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis.

What is the brand name for dabigatran?

Dabigatran is used to prevent blood clots from forming because of a certain irregular heart rhythm (atrial fibrillation). Preventing these blood clots helps to reduce the risk of a stroke. Dabigatran is available under the following different brand names: Pradaxa.

What is the brand name for argatroban?

Acova (argatroban) dosing, indications, interactions, adverse effects, and more.

Is Lepirudin still used?

Bayer announced that it ceased the production of lepirudin (Refludan) on May 31, 2012.

Is Lepirudin an anticoagulant?

Lepirudin is a recombinant form of hirudin, an endogenous anticoagulant found in medicinal leeches. Lepirudin forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen and initiate the clotting cascade.

Is Pradaxa better than warfarin?

In a clinical trial, PRADAXA was proven to work better than warfarin at reducing the risk of stroke due to AFib not caused by a heart valve problem.

What is the generic name for Pradaxa?

There is currently no generic for Pradaxa (dabigatran), so it can be expensive, even with insurance.

How is argatroban monitored?

Argatroban is monitored using the activated partial thromboplastin time (aPTT). The goal aPTT in seconds has been defined at UWMC/HMC as 60-80 seconds. Alternatively, it can be monitored with the direct thrombin inhibitor assay available at UWMC/HMC.