Which drugs have a narrow therapeutic index?
Drugs with a narrow therapeutic index 4 We defined the following drugs to be NTI-drugs: aminoglycosides, ciclosporin, carbamazepine, digoxin, digitoxin, flecainide, lithium, phenytoin, phenobarbital, rifampicin, theophylline and warfarin.
Which antibiotic has the narrowest therapeutic index?
Most antibiotics, such as the β-lactams, macrolides and quinolones have a wide therapeutic index and therefore do not require therapeutic drug monitoring. Some, such as the aminoglycosides and vancomycin, have a narrow therapeutic index, and toxicity may be severe and irreversible.
Is there a narrow therapeutic index?
Some drugs have a narrow therapeutic index, which means that there is only a small difference between the minimum effective concentrations and the minimum toxic concentrations in the blood. With such drugs, small increases in dose or in blood/serum concentrations could lead to toxic effects.
Which of the following is an example of a narrow therapeutic index NTI medication?
Example NTI drugs include warfarin, levothyroxine, carbamazepine, digoxin, lithium carbonate, phenytoin, and theophylline.
What does a narrow therapeutic index mean?
Introduction. Narrow therapeutic index drugs are drugs where small differences in dose or blood concentration may lead to serious therapeutic failures and/or adverse drug reactions that are life-threatening or result in persistent or significant disability or incapacity.
What is the use of narrow therapeutic index?
The concept of an NTI is important for proper use of drugs in medical practice. It is used by clinicians with the subjective but useful notion that drug doses or plasma concentrations associated with a desired therapeutic response are in close proximity to those associated with adverse reactions.
Is a high therapeutic index good?
A higher therapeutic index is preferable to a lower one: a patient would have to take a much higher dose of such a drug to reach the toxic threshold than the dose taken to elicit the therapeutic effect.
What does it mean if a drug has a narrow therapeutic index?
What is a good therapeutic index?
A higher therapeutic index is preferable to a lower one: a patient would have to take a much higher dose of such a drug to reach the toxic threshold than the dose taken to elicit the therapeutic effect….Therapeutic index.
| Term | Meaning |
|---|---|
| TR | Therapeutic Ratio |
What is a wide therapeutic index?
Drugs with a high therapeutic index have a wide margin of safety and less danger of producing toxic effects. Plasma drug levels do not need to be monitored routinely for drugs with a high therapeutic index.
What is considered a high therapeutic index?
A higher therapeutic index is preferable to a lower one: a patient would have to take a much higher dose of such a drug to reach the toxic threshold than the dose taken to elicit the therapeutic effect….Therapeutic index.
| Term | Meaning |
|---|---|
| TI | Therapeutic Index |
| TR | Therapeutic Ratio |
What causes narrow therapeutic index?
Narrow therapeutic index drugs are drugs where small differences in dose or blood concentration may lead to serious therapeutic failures and/or adverse drug reactions that are life-threatening or result in persistent or significant disability or incapacity.
What is the definition of narrow therapeutic index?
• Narrow therapeutic index (NTI) drugs are defined as those drugs where small differences in dose or blood concentration may lead to dose and blood concentration dependent, serious therapeutic failures or adverse drug reactions.
What are bioequivalence standards for narrow therapeutic index drugs?
Quality and Bioequivalence Standards for Narrow Therapeutic Index Drugs Lawrence X. Yu, Ph.D. Deputy Director for Science and Chemistry Office of Generic Drugs Center for Drug Evaluation and Research Food and Drug Administration GPhA 2011 Fall Technical Workshop 2 Bioequivalence
How to limit generic substitution for narrow therapeutic index drugs?
–…limit generic substitution by the pharmacist for drugs with a Narrow Therapeutic Index (NTI)…NTI drugs include some anti-epileptic drugs, warfarin]
What do you call drugs with a narrow therapeutic range?
Other terms also used include ‘drugs with a narrow therapeutic window’, ‘narrow therapeutic range’, ‘critical dose drugs’ or ‘narrow therapeutic ratio’.