What is the function and structure of Golgi apparatus?
The Golgi apparatus is a central intracellular membrane-bound organelle with key functions in trafficking, processing, and sorting of newly synthesized membrane and secretory proteins and lipids. To best perform these functions, Golgi membranes form a unique stacked structure.
Who described the Golgi apparatus what is their function?
Camillo Golgi
The existence of the cell organelle which is now known as Golgi apparatus or Golgi complex, or simply as ‘the Golgi”, was first reported by Camillo Golgi in 1898, when he described in nerve cells an ‘internal reticular apparatus’ impregnated by a variant of his chromoargentic staining.
How does the Golgi apparatus cause Alzheimer’s?
A recent study on Alzheimer’s disease (AD) revealed that phosphorylation of the Golgi stacking protein GRASP65 disrupts its function in Golgi structure formation, resulting in Golgi fragmentation. Inhibiting GRASP65 phosphorylation restores the Golgi morphology from Aβ-induced fragmentation and reduces Aβ production.
What is a Golgi apparatus simple definition?
(GOL-jee A-puh-RA-tus) A stack of small flat sacs formed by membranes inside the cell’s cytoplasm (gel-like fluid). The Golgi apparatus prepares proteins and lipid (fat) molecules for use in other places inside and outside the cell. The Golgi apparatus is a cell organelle. Also called Golgi body and Golgi complex.
What diseases does the Golgi apparatus cause?
Structural and functional changes of the Golgi apparatus are associated with several neurodegenerative diseases, such as Amyotrophic lateral sclerosis (28), Alzheimer’s disease (29), Parkinson’s disease (3), Huntington’s disease (30), Creutzfeldt-Jacob disease (31) and multiple system atrophy (32).
What happens if the Golgi apparatus is damaged?
In the absence of the Golgi apparatus, lysosomes would not be produced, and the accumulation of dead and damaged organelles and molecules in the cell would ultimately result in cell death. If the Golgi apparatus is not present the packaging and transport of materials would cease.
What is function of ribosome?
A ribosome functions as a micro-machine for making proteins. Ribosomes are composed of special proteins and nucleic acids. The TRANSLATION of information and the Linking of AMINO ACIDS are at the heart of the protein production process.
Where is the Golgi apparatus located in the cell?
What is the Golgi apparatus? The Golgi apparatus, also called Golgi complex or Golgi body, is a membrane-bound organelle found in eukaryotic cells (cells with clearly defined nuclei) that is made up of a series of flattened stacked pouches called cisternae. It is located in the cytoplasm next to the endoplasmic reticulum and near the cell nucleus.
How are proteoglycans added to the Golgi apparatus?
Proteoglycans are proteins that have been glycosylated, meaning that they have had a carbohydrate attached to them. Enzymes found within the Golgi apparatus add proteins to the glycosaminoglycans, which are long molecules of polysaccharides found within the extracellular matrix.
How many cisternae does the Golgi apparatus have?
Some protists have Golgi bodies with as many as sixty cisternae per stack, however. The location of the Golgi apparatus varies between eukaryotic organisms.
How many compartments are there in the Golgi stack?
The Golgi body comprises 5 to 8 cup-shaped, series of compartments known as cisternae. Cisternae is a flattened, disk-shaped, stacked pouches that make up the Golgi apparatus. A Golgi stack mostly contains 4 to 8 cisternae.