What are the seven types of episodic ataxia?
The following information is based on reports within single families.
- Episodic ataxia type 3 (EA3). EA3 is associated with vertigo, tinnitus, and migraine headaches.
- Episodic ataxia type 4 (EA4).
- Episodic ataxia type 5 (EA5).
- Episodic ataxia type 6 (EA6).
- Episodic ataxia type 7 (EA7).
- Episodic ataxia type 8 (EA8).
What triggers episodic ataxia?
Episodic ataxia can be caused by mutations in several genes that play important roles in the nervous system. Three of these genes, KCNA1, CACNA1A, and CACNB4, provide instructions for making proteins that are involved in the transport of charged atoms (ions) across cell membranes .
Does episodic ataxia go away?
The symptoms of episodic ataxia may disappear as a person gets older, although sometimes the condition gets gradually worse over time. Medication can often help control attacks, and life expectancy is usually normal.
Is episodic ataxia a rare disease?
The autosomal dominant ataxias, also called the spinocerebellar ataxias, are usually identified as SCA1 through SCA37. Also included are several “episodic ataxias”, as well as a very rare disorder known as DRPLA (dentato-rubro-pallido-luysian atrophy).
How long does an episode of episodic ataxia last?
Episodic ataxia refers to a group of conditions that affect the central nervous system. It affects specific nerve fibers that carry messages to and from the brain in order to control body movement. The condition causes episodes of poor coordination and balance (ataxia). Episodes may last from a few seconds to several hours.
What causes episodic ataxia type 2 ( EA 2 )?
Episodic ataxia type 2 (EA 2) is a rare neurological disorder of autosomal dominant inheritance resulting from dysfunction of a voltage-gated calcium channel. It manifests with recurrent disabling attacks of imbalance, vertigo, and ataxia, and can be provoked by physical exertion or emotional stress …
Are there any new drugs for episodic ataxia?
Treatment of episodic ataxia. The mouse models of EA2 provide an excellent system to test the efficacy of currently used drugs and the potential to develop new drugs for treating the episodic ataxia syndromes. 4-aminopyridine and 3,4-diaminopyridine were effective in preventing attacks in the mouse model tottering,…
Is there a registry for patients with ataxia?
Coordination of Rare Diseases at Sanford (CoRDS) hosts a specific registry for patients with ataxia in partnership with the National Ataxia Foundation. The goal of the CoRDS registry is to connect as many patients and researchers as possible to help advance treatments and cures for rare diseases.