What is an atopic response?
Atopic reactions (commonly caused by mite feces, animal dander, pollen, or mold) are IgE-mediated allergic reactions that trigger histamine release.
What happens in atopy?
This condition, also known as atopic dermatitis, causes itchy, dry, red, and inflamed skin. It often happens inside the elbows, on the backs of the knees, and on the face and scalp. Your skin can flare up in response to allergic triggers such as soap or detergent.
What is an atopic history?
The allergic march refers to the natural history of atopic disorders. The allergic march concerns the development of atopic dermatitis and concomitant sensitization to food and aeroallergens in early childhood, progressing to asthma and allergic rhinitis in later childhood or adult life (3).
What are the causes of atopy?
The main triggers of atopic dermatitis are dry skin, irritants, stress, allergies, infection and heat/sweating. It’s important to note that these are triggers that worsen the symptoms of atopic dermatitis, and don’t necessarily cause atopic dermatitis.
Is atopy the same as allergy?
Atopy is an exaggerated IgE-mediated immune response; all atopic disorders are type I hypersensitivity disorders. Allergy is any exaggerated immune response to a foreign antigen regardless of mechanism.
Is atopy hereditary?
The genetics of atopic dermatitis are not completely understood. Studies suggest that several genes can be involved in development of the condition. In very rare cases, atopic dermatitis is caused by inherited mutations in a single gene.
Is atopy a diagnosis?
No lab test is needed to identify atopic dermatitis (eczema). Your doctor will likely make a diagnosis by examining your skin and reviewing your medical history. He or she may also use patch testing or other tests to rule out other skin diseases or identify conditions that accompany your eczema.
Which is the best definition of ” atopy “?
Definition of atopy : a genetic disposition to develop an allergic reaction (such as allergic rhinitis or asthma) and produce elevated levels of IgE upon exposure to an environmental antigen and especially one inhaled or ingested
What is the pathophysiologic basis for the development of atopy?
The pathophysiologic basis for subjects developing atopy is uncertain and is the topic of a recent symposium [28]. An old hypothesis favoring allergen handling perhaps at the mucosal surface [29] rather than increased capacity to produce IgE has not been excluded.
Is there any clinical evidence for atopy disease?
Clinical evidence. Atopy is clearly associated with increased risk of sensitization to HMW agents.
Why do people with atopy develop IgE antibodies?
Atopy is the tendency to develop IgE antibodies to commonly encountered environmental allergens by natural exposure in which the route of entry of allergen is across intact mucosal surfaces [26]. The recognized familial nature of atopy is due to complex (multiple gene) inheritance (genetic heterogeneity) [21, 27].