What functional groups are in metoprolol?
Metoprolol is a propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1. It has a role as a beta-adrenergic antagonist, an antihypertensive agent, a xenobiotic and an environmental contaminant.
What is metoprolol mechanism of action?
Mechanism of Action Metoprolol is a cardioselective beta-1-adrenergic receptor inhibitor that competitively blocks beta1-receptors with minimal or no effects on beta-2 receptors at oral doses of less than 100 mg in adults. It decreases cardiac output by negative inotropic and chronotropic effects.
What are the four actions of metoprolol?
Clinical pharmacology studies have demonstrated the beta-blocking activity of Metoprolol, as shown by (1) reduction in heart rate and cardiac output at rest and upon exercise, (2) reduction of systolic blood pressure upon exercise, (3) inhibition of isoproterenol-induced tachycardia, and (4) reduction of reflex …
What is the structure of metoprolol?
C15H25NO3
Metoprolol/Formula
What are the most common side effects of metoprolol?
Metoprolol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- dizziness or lightheadedness.
- tiredness.
- depression.
- nausea.
- dry mouth.
- stomach pain.
- vomiting.
- gas or bloating.
How does metoprolol work as an adrenergic antagonist?
Metoprolol acts as ß 1 -adrenergic antagonist for the cardiac cells. By producing negative inotropic effects, there is decrease in the cardiac output. [1] Increasing the chain length of the side chain prevents appropriate binding of the required functional groups to the same receptors side.
How does metoprolol work in the myocardium?
Metoprolol is a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction leading to a reduction in cardiac output.
Where can I find the synthesis of metoprolol?
Synthesis and preparations of metoprolol and its salts. United States patent application US 12/158,950. 2009 Oct 1. Search If playback doesn’t begin shortly, try restarting your device. An error occurred while retrieving sharing information. Please try again later. Use Up/Down Arrow keys to increase or decrease volume.
What are the off label uses of metoprolol?
Metoprolol is indicated for the treatment of angina, heart failure, myocardial infarction, atrial fibrillation, atrial flutter and hypertension. Some off-label uses of metoprolol include supraventricular tachycardia and thyroid storm.