What is VDRL and Tpha test?

specific tests, which detect antitreponemal antibody. The most widely used cardiolipin and specific tests. are respectively the Venereal Disease Research. Laboratory (VDRL) test’ and the Treponema. pallidum haemagglutination (TPHA) test.2 Both are.

What does it mean when VDRL is non reactive?

A reactive CSF-VDRL test, free of blood or other contaminants, usually indicates past or present syphilis infection of the central nervous system (CNS). A BFP test result is rare in spinal fluid. A nonreactive VDRL test may indicate that the patient does not have neurosyphilis.

What is a high titer for syphilis?

A positive RPR test should be followed by another type of test to diagnose syphilis. If you have been treated for syphilis in the past, an RPR test that shows a titer increase of fourfold means you likely have a new syphilis infection if you were not fully treated in the past.

How do you read a syphilis titer?

Syphilis antibodies should be lower following treatment. For example, if the RPR was initially reported as 1:256, a value of 1:16 after treatment would indicate a lower level of antibody. If the titer remains the same or rises, the affected person may have a persistent infection or was reinfected.

What happens if TPHA positive?

If your test results come out to be positive TPHA disease it is imperative to undergo the complete treatment. The TPHA positive treatment requires you to complete the full antibiotics course even if the symptoms subside. Failing to do so can trigger a relapse.

What is Tpha test in pregnancy?

In order to determine whether pregnancy influences the specificity of the fluorescent treponemal antibody absorption (FTA-ABS) and Treponema palidum haemagglutination assay (TPHA) tests, these tests, together with the quantitative fluorescent treponemal antibody (FTA) and Venereal Disease Research Laboratory (VDRL) …

Can TPHA be false positive?

Treponemal tests such as TPHA, having lower sensitivities in primary syphilis, remain positive despite treatment and give false positive results uncommonly.

What is TPHA negative?

A negative test result means that antibodies against Treponema Pallidum are absent indicating that the patient is not having syphilis infection. A positive test result means that antibodies against Treponema Pallidum are present indicating that the patient is having syphilis infection.

How do you read TPHA results?

The TPHA test meaning can be interpreted by the agglutination intensity that could range from – to 4+. Understanding these cases gives a clear picture of the TPHA positive results. 1. It is 4+ if there is a uniform mat of the cells covering the entire well.

What are normal titer levels?

The normal values of an antibody titer depend on the type of antibody. If the testing is done to detect autoantibodies, the normal value should essentially be zero or negative. In the case of testing the efficacy of a vaccine, the normal test result depends on the definite value that is specific for that immunization.

Can TPHA be negative after treatment?

The response of the Treponema Pallidum Haemagglutination Assay (TPHA) to treatment was studied in 61 cases of early infectious syphilis. In none of the 55 cases of early syphilis in which the pre-treatment TPHA was positive did the TPHA test become consistently negative after treatment.