What is factor VIIa?
Factor VIIa is a man-made protein produced to replicate the naturally occurring activated factor VII (factor VIIa) in the body. It is used to stop bleeding of injuries for patients with hemophilia by helping the blood to clot.
When do you use NovoSeven?
INDICATIONS AND USAGE
- NovoSeven is indicated for:
- Factor IX and in patients with acquired hemophilia.
- patients with inhibitors to Factor VIII or Factor IX and in patients with acquired hemophilia.
- • prevention of bleeding in surgical interventions or invasive procedures in patients with.
How much does factor 7 cost?
NovoSeven is recombinant human activated factor VII (FVII), a hemostatic agent that is similar to human plasma-derived FVIIa. In 2014, the average wholesale price of NovoSeven was $1.71 per mcg. For a patient weighing 70 kg (154 lb) then, the cost of a typical 90 µg/kg dose was $9,480 (rounding to decrease waste).
What is the 7th clotting factor?
Factor VII is a protein produced in the liver that plays an important role in helping your blood to clot. It’s one of about 20 clotting factors involved in the complex process of blood clotting.
How does Recombinant activated factor VII ( rFVIIa ) work?
We performed this phase 3 trial to confirm a previous study in which recombinant activated factor VII (rFVIIa) reduced growth of the hematoma and improved survival and functional outcomes.
How is NovoSeven similar to human factor VIIa?
NovoSeven is structurally similar to human plasma-derived Factor VIIa. The gene for human Factor VII is cloned and expressed in baby hamster kidney cells (BHK cells). Recombinant FVII is secreted into the culture media (containing newborn calf serum) in
Which is a recombinant human coagulation factor VIIa?
NovoSeven®is recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade.1NovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues (MW 50 K Dalton). NovoSeven is structurally similar to human plasma-derived Factor VIIa.
How long does it take to clot with 10 nm factor VIIa?
Clotting of CTI-inhibited (0.1 mg/mL) normal blood initiated with 12.5 pM TF ( ) and addition of 10 nM factor VIIa ( ) and of hemophilia A blood with ( ) and without ( ) addition of 10 nM factor VIIa. Figure A shows TAT generation over time. Arrows indicate clotting times. Figure B 0 30 60 90 120 150 180 0 1020 30 4050 60 Time (min)