What is Dedifferentiated thyroid cancer?

Abstract. Dedifferentiated thyroid cancer (DeTC) derived from follicular epithelium is often incurable because it does not respond to radioiodine, radiotherapy, or chemotherapy.

Is metastatic papillary thyroid cancer curable?

Papillary thyroid cancer is usually very curable if you have an expert team of doctors involved in your care. Followed by expert comprehensive evaluation, having the correct first operation is the most critical task of the patient with a new or suspicious diagnosis of papillary thyroid cancer.

How long can you live with papillary thyroid cancer?

The bottom line is that most thyroid cancers are papillary thyroid cancer, and this is one of the most curable cancers of all cancers. More than 98% of patients with papillary thyroid cancer remain alive after five years.

What is the most aggressive thyroid cancer?

Anaplastic carcinoma (also called giant and spindle cell cancer) is the most dangerous form of thyroid cancer. It is rare, and spreads quickly. Follicular tumor is more likely to come back and spread.

Is follicular thyroid cancer aggressive?

Follicular carcinoma (also called Follicular thyroid cancer) is called a “well differentiated” thyroid cancer like papillary thyroid cancer, but it is typically a bit more malignant (aggressive) than papillary cancer.

Where does thyroid cancer metastasize first?

In 10 (38.5%) patients distant metastasis beyond the regional lymph nodes was the first sign of thyroid cancer. In (50%) patients metastasis was located in the bones, in 2 (20%) in the lung, in 1 (10%) in the heart, in 1 (10%) in the buttock, and in 1 (10%) in a central neck cyst.

What are the signs of thyroid cancer returning?

Signs and symptoms of thyroid cancer recurrence may include:

  • Neck swelling or a lump in the neck that may grow rapidly.
  • Neck pain that starts in the front of the neck and sometimes extends to the ears.
  • Trouble breathing or swallowing.
  • Voice changes or hoarseness.
  • Continuous cough not related to a cold.

Does thyroid cancer spread easily?

It can grow quickly and often spreads into surrounding tissue and other parts of the body. This rare cancer type accounts for about 2% of thyroid cancer diagnoses.

How to treat de-differentiation of papillary thyroid carcinoma?

De-differentiation from papillary thyroid carcinoma to squamous cell carcinoma. The patient underwent a total thyroidectomy at the initial hospital and received high dose radioactive iodine (RAI) treatment at our hospital 1 month following the surgery and then was lost to follow-up.

Are there any rare cases of thyroid cancer?

The unpredictability of thyroid cancer can be striking, as the disease may rapidly progress to death in some individuals. Herein, we reported a rare case of aggressive papillary thyroid cell carcinoma (PTC) in an elderly patient de-differentiated into squamous cell carcinoma (SCC).

What is the prognosis for de-differentiation of thyroid cancer?

De-differentiation from well-differentiated thyroid cancer into poorly differentiated thyroid cancer and/or anaplastic thyroid carcinoma is frequently reported with dismal prognosis (<1 year in most cases). [6]

Which is the most common type of thyroid cancer?

Papillary thyroid carcinoma (PTC) is the most common thyroid cancer with its incidence having doubled over the past 2 decades from a widespread use of imaging to detect subclinical thyroid nodules rather than clinically significant PTC. [1] Most patients with PTC have excellent prognosis with a 10-year survival rate of over 90%. [2]