What are Cholinomimetic drugs used for?

Used in treatment of postpartum or postoperative urinary retention and neurogenic atonic bladder. Used in treatment of neurogenic ileus and congenital megacolon.

What’s a cholinergic drug?

Cholinergic medications are a category of pharmaceutical agents that act upon the neurotransmitter acetylcholine, the primary neurotransmitter within the parasympathetic nervous system (PNS). There are two broad categories of cholinergic drugs: direct-acting and indirect-acting.

What is physostigmine used for?

Physostigmine salicylate has FDA approval for use in the treatment of glaucoma and the treatment of anticholinergic toxicity. It is useful to treat the central nervous system effects of anticholinergic toxicity due to its ability to cross the blood-brain barrier.

Which one is a Cholinomimetic agent?

A parasympathomimetic drug, sometimes called a cholinomimetic drug or cholinergic receptor stimulating agent, is a substance that stimulates the parasympathetic nervous system (PSNS). These chemicals are also called cholinergic drugs because acetylcholine (ACh) is the neurotransmitter used by the PSNS.

Where is ACh used?

neuromuscular junction
Acetylcholine is the neurotransmitter used at the neuromuscular junction—in other words, it is the chemical that motor neurons of the nervous system release in order to activate muscles.

What does ACh do in the body?

Acetylcholine is the chief neurotransmitter of the parasympathetic nervous system, the part of the autonomic nervous system (a branch of the peripheral nervous system) that contracts smooth muscles, dilates blood vessels, increases bodily secretions, and slows heart rate.

What happens during physostigmine poisoning?

Antagonism of muscarinic receptors may lead to an antimuscarinic toxidrome characterized peripherally by tachycardia, mild hyperthermia, mydriasis, diminished bowel sounds, dry skin, urinary retention, and picking behavior. Delirium is the primary central manifestation of antimuscarinic poisoning.

Which drug shows Parasympatholytic action?


Drug Drug Description
Dicyclomine An antimuscarinic agent used to treat IBS.
Biperiden A muscarinic receptor antagonist used to treat parkinsonism and control extrapyramidal side effects of neuroleptic drugs.
Cyclopentolate An anticholinergic used to cause mydriasis and cycloplegia for diagnostic testing.

Why are cholinergic drugs called cholinomimetic drugs?

A parasympathomimetic is a drug or poison that acts by stimulating or mimicking the parasympathetic nervous system (PNS). These chemicals are also called cholinomimetic drugs or cholinergics because acetylcholine (ACh) is the neurotransmitter used by the PNS.

How are cholinomimetics used in the autonomic nervous system?

Cholinomimetics are an important class of drugs affecting the autonomic nervous system. They act on receptors that are activated by acetylcholine. They are broadly classified into direct-acting and indirect-acting drugs. In this article, we will study the mechanism of action and pharmacological actions,…

How are indirect acting cholinomimetics used in medicine?

Indirect-acting cholinomimetics inhibit acetylcholinesterase – an enzyme present in cholinergic synapses that causes hydrolysis of acetylcholine. Chemically, they can be classified into simple alcohols, bearing a quaternary ammonium group (e.g., edrophonium), carbamates (e.g., neostigmine) and organophosphates (e.g., echothiophate).

What is the negative effect of cholinomimetic agents on the heart?

Negative dromotropic effect (reduction in conduction velocity) by action on the atrioventricular node (M2 receptors) in the heart, thus increasing the refractory period.