What is the incidence or rate of occurrence of Klinefelter syndrome?
47, XXY (KS) is the most common human sex chromosome disorder and occurs in approximately 1 in 500-1,000 males. It is estimated that 3,000 affected boys are born each year in the United States.
What is the ratio of Klinefelter syndrome?
Klinefelter syndrome affects about 1 in 650 newborn boys. It is among the most common sex chromosome disorders, which are conditions caused by changes in the number of sex chromosomes (the X chromosome and the Y chromosome).
What is the survival rate of Klinefelter syndrome?
We found that Klinefelter syndrome was associated with a significant increase in mortality risk of 40% (hazard ratio, 1.40; 95% confidence interval, 1.13-1.74), corresponding to a significantly reduced median survival of 2.1 yr.
What type of numerical abnormalities is Klinefelter syndrome?
Klinefelter syndrome (XXY aneuploidy) is the most common human sex chromosome disorder. Approximately 1 in 500-600 males is born with an extra X chromosome.
Who is most likely to have Klinefelter syndrome?
Klinefelter syndrome results when a boy is born with at least 1 extra X chromosome. This is written as XXY. Klinefelter syndrome occurs in about 1 out of 500 to 1,000 baby boys. Women who get pregnant after age 35 are slightly more likely to have a boy with this syndrome than younger women.
Who is affected by Klinefelter syndrome?
Boys and men with Klinefelter syndrome are still genetically male, and often will not realise they have this extra chromosome, but occasionally it can cause problems that may require treatment. Klinefelter syndrome affects around 1 in every 660 males.
What is Klinefelter syndrome syndrome?
Klinefelter syndrome (sometimes called Klinefelter’s, KS or XXY) is where boys and men are born with an extra X chromosome. Chromosomes are packages of genes found in every cell in the body. There are 2 types of chromosome, called the sex chromosomes, that determine the genetic sex of a baby.
Is Klinefelter’s a disability?
If you or your dependent(s) are diagnosed with Klinefelter Syndrome and experience any of these symptoms, you may be eligible for disability benefits from the U.S. Social Security Administration.
Is Klinefelter syndrome a disability?
What happens to a person with Klinefelter syndrome?
Klinefelter syndrome (KS) is a condition that occurs in males when they have an extra X chromosome. Some males with KS have no obvious signs or symptoms while others may have varying degrees of cognitive, social, behavioral, and learning difficulties. Adults with Klinefelter syndrome may also have primary hypogonadism
Is there an extra X chromosome in Klinefelter syndrome?
Most often, Klinefelter syndrome is the result of one extra X (written as XXY). Occasionally, variations of the XXY chromosome count may occur, the most common being the XY/XXY mosaic. In this variation, some of the cells in the male’s body have an additional X chromosome, and the rest have the normal XY chromosome count.
What are the causes of Mosaic Klinefelter syndrome?
Klinefelter syndrome can be caused by: 1 One extra copy of the X chromosome in each cell (XXY), the most common cause 2 An extra X chromosome in some of the cells (mosaic Klinefelter syndrome), with fewer symptoms 3 More than one extra copy of the X chromosome, which is rare and results in a severe form
When was Klinefelter syndrome discovered and what year?
In 1956 it was discovered that Klinefelter syndrome resulted from an extra chromosome. Plunkett and Barr found the sex chromatin body in cell nuclei of the body. This was further clarified as XXY in 1959 by Patricia Jacobs and John Anderson Strong.