What does PGC 1 alpha do?
PGC-1alpha stimulates mitochondrial biogenesis and promotes the remodeling of muscle tissue to a fiber-type composition that is metabolically more oxidative and less glycolytic in nature, and it participates in the regulation of both carbohydrate and lipid metabolism.
What activates pgc1 Alpha?
PGC-1α was originally found to be activated in brown fat and muscle cells on cold exposure (see Figure 1). Cold temperatures are sensed by the sympathetic nervous system through the β3-adrenergic receptor (β3-AR) (4, 26, 27), leading to enhanced cAMP signaling and the activation of protein kinase A (PKA).
What does PGC stand for?
|PGC||Public Governance Committee (Organisation for Economic Co-operation and Development)|
|PGC||Potassium Gold Cyanide|
|PGC||Process Gas Chromatography|
|PGC||Plan Général de Coordination (French: General Coordination Plan)|
Is PGC 1a a transcription factor?
PGC-1a then co-activates transcription factors such as nuclear respiratory factors (NRFs), estrogen-related receptors (ERRs), and PPARs, known to regulate different aspects of energy metabolism including mitochon- drial biogenesis, fatty acid oxidation, and antioxidant.
Is PGC1a a transcription factor?
PGC1a is a transcription factor coactivator that influences a majority of cellular metabolic pathways. Abnormal expression of PGC1a is associated with several chronic diseases and, in recent years, it has been shown to be a critical controller of cancer development.
What does PGC mean in texting?
Technology, IT etc (10) PGC — Pre Game Chat.
What does PGC stand for in education?
From Wikipedia, the free encyclopedia. A postgraduate certificate (abbreviated as PGCert, PgCert, PG Cert, PGC, or PgC is a postgraduate qualification at the level of a master’s degree.
What are the key transcription factors in muscle tissue affected by exercise?
Acute exercise increased gene expression of the nuclear hormone receptor 4A (NR4A) subfamily (∼4- to 36-fold) and other key transcription factors, including ATF3, EGR1, JUNB, SIK1, PPARA, and PPARG (∼1.5- to 12-fold), but with no differences between groups.
What do coactivators do?
Coactivators function as adaptors in a signaling pathway that transmits transcriptional responses from the DNA bound receptor to the basal transcriptional machinery.
What is the Pparg gene?
PPARG (Peroxisome Proliferator Activated Receptor Gamma) is a Protein Coding gene. Diseases associated with PPARG include Lipodystrophy, Familial Partial, Type 3 and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Glucose / Energy Metabolism and Developmental Biology.
What is full form of PGC?
PGC Full Form
|Program Chain||Computer Technology||PGC|
|PANCHGACHIA||Indian Railway Station||PGC|
|Plant Growth (unit)||Space Science||PGC|
|Plant Growth Chamber||Space Science||PGC|
What does PGC student mean?
PGC. Post Graduate Certificate. Business » Certifications & Diplomas.
How is PGC-1alpha related to thermogenesis?
Peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha is a member of a family of transcription coactivators that plays a central role in the regulation of cellular energy metabolism. It is strongly induced by cold exposure, linking this environmental stimulus to adaptive thermogenesis.
Where is PGC-1α located in the cell?
PGC-1α has two putative nuclear localization signals and is located in the cell nucleus ( 49 ). It is expressed at high levels in tissues where mitochondria are abundant and oxidative metabolism is active, such as brown adipose tissue (BAT), the heart, and skeletal muscle.
Which is a positive feedback circuit of PGC-1α?
PGC-1α has been shown to exert positive feedback circuits on some of its upstream regulators: PGC-1α increases Akt (PKB) and Phospho-Akt (Ser 473 and Thr 308) levels in muscle. PGC-1α leads to calcineurin activation. Akt and calcineurin are both activators of NF kappa B (p65).
How does PGC-1 α affect the inflammatory response?
Dysregulation of PGC-1 α alters redox homeostasis in cells and exacerbates inflammatory response, which is commonly accompanied by metabolic disturbances. During inflammation, low levels of PGC-1 α downregulate mitochondrial antioxidant gene expression, induce oxidative stress, and promote nuclear factor kappa B activation.