What does PGC 1 alpha do?

PGC-1alpha stimulates mitochondrial biogenesis and promotes the remodeling of muscle tissue to a fiber-type composition that is metabolically more oxidative and less glycolytic in nature, and it participates in the regulation of both carbohydrate and lipid metabolism.

What activates pgc1 Alpha?

PGC-1α was originally found to be activated in brown fat and muscle cells on cold exposure (see Figure 1). Cold temperatures are sensed by the sympathetic nervous system through the β3-adrenergic receptor (β3-AR) (4, 26, 27), leading to enhanced cAMP signaling and the activation of protein kinase A (PKA).

What does PGC stand for?


Acronym Definition
PGC Public Governance Committee (Organisation for Economic Co-operation and Development)
PGC Potassium Gold Cyanide
PGC Process Gas Chromatography
PGC Plan Général de Coordination (French: General Coordination Plan)

Is PGC 1a a transcription factor?

PGC-1a then co-activates transcription factors such as nuclear respiratory factors (NRFs), estrogen-related receptors (ERRs), and PPARs, known to regulate different aspects of energy metabolism including mitochon- drial biogenesis, fatty acid oxidation, and antioxidant.

Is PGC1a a transcription factor?

PGC1a is a transcription factor coactivator that influences a majority of cellular metabolic pathways. Abnormal expression of PGC1a is associated with several chronic diseases and, in recent years, it has been shown to be a critical controller of cancer development.

What does PGC mean in texting?

Technology, IT etc (10) PGC — Pre Game Chat.

What does PGC stand for in education?

From Wikipedia, the free encyclopedia. A postgraduate certificate (abbreviated as PGCert, PgCert, PG Cert, PGC, or PgC is a postgraduate qualification at the level of a master’s degree.

What are the key transcription factors in muscle tissue affected by exercise?

Acute exercise increased gene expression of the nuclear hormone receptor 4A (NR4A) subfamily (∼4- to 36-fold) and other key transcription factors, including ATF3, EGR1, JUNB, SIK1, PPARA, and PPARG (∼1.5- to 12-fold), but with no differences between groups.

What do coactivators do?

Coactivators function as adaptors in a signaling pathway that transmits transcriptional responses from the DNA bound receptor to the basal transcriptional machinery.

What is the Pparg gene?

PPARG (Peroxisome Proliferator Activated Receptor Gamma) is a Protein Coding gene. Diseases associated with PPARG include Lipodystrophy, Familial Partial, Type 3 and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Glucose / Energy Metabolism and Developmental Biology.

What is full form of PGC?

PGC Full Form

Full Form Category Term
Program Chain Computer Technology PGC
PANCHGACHIA Indian Railway Station PGC
Plant Growth (unit) Space Science PGC
Plant Growth Chamber Space Science PGC

What does PGC student mean?

PGC. Post Graduate Certificate. Business » Certifications & Diplomas.

How is PGC-1alpha related to thermogenesis?

Peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha is a member of a family of transcription coactivators that plays a central role in the regulation of cellular energy metabolism. It is strongly induced by cold exposure, linking this environmental stimulus to adaptive thermogenesis.

Where is PGC-1α located in the cell?

PGC-1α has two putative nuclear localization signals and is located in the cell nucleus ( 49 ). It is expressed at high levels in tissues where mitochondria are abundant and oxidative metabolism is active, such as brown adipose tissue (BAT), the heart, and skeletal muscle.

Which is a positive feedback circuit of PGC-1α?

PGC-1α has been shown to exert positive feedback circuits on some of its upstream regulators: PGC-1α increases Akt (PKB) and Phospho-Akt (Ser 473 and Thr 308) levels in muscle. PGC-1α leads to calcineurin activation. Akt and calcineurin are both activators of NF kappa B (p65).

How does PGC-1 α affect the inflammatory response?

Dysregulation of PGC-1 α alters redox homeostasis in cells and exacerbates inflammatory response, which is commonly accompanied by metabolic disturbances. During inflammation, low levels of PGC-1 α downregulate mitochondrial antioxidant gene expression, induce oxidative stress, and promote nuclear factor kappa B activation.