What are azole agents?
Azole antifungal agents have added greatly to the therapeutic options for treatment of systemic fungal infections. The azoles that are available for systemic use can be classified into two groups: the triazoles (fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole) and the imidazoles (ketoconazole).
Which is a azole containing antifungal drug?
What is the indication of azole antifungal agents?
Azole antifungal agents can be used to treat fungal infections of the body and skin, including athlete’s foot, onychomycosis (fungal nail infections), ringworm, and vaginal candidiasis.
What drugs end in azole?
Triazole agents, which are now the most commonly used azoles, include fluconazole, itraconazole, econazole, terconazole, butoconazole, and tioconazole.
Which azole is best?
Major developments in research into the azole class of antifungal agents during the 1990s have provided expanded options for the treatment of many opportunistic and endemic fungal infections. Fluconazole and itraconazole have proved to be safer than both amphotericin B and ketoconazole.
What are the advantages of using azole antifungal agents?
It is more effective than ketoconazole against superficial candidal infections and is the drug of choice for maintenance therapy for cryptococcal meningitis in patients infected with human immunodeficiency virus. An advantage of itraconazole is its activity against aspergillosis.
Which azole is most hepatotoxic?
However, histopathological changes revealed that fluconazole was the most hepatotoxic, followed by ketoconazole, itraconazole, terbinafine, and griseofulvin, respectively.
What is the strongest antifungal medication?
1. Terbinafine is more effective than griseofulvin, and can clear onychomycosis in 12 weeks rather than 12 months. 2. Ketoconazole is the treatment of choice for pityriasis rosea.
What is the best antifungal ingredient?
Most fungal infections respond well to these topical agents, which include:
- Clotrimazole (Lotrimin AF) cream or lotion.
- Miconazole (Micaderm) cream.
- Selenium sulfide (Selsun Blue) 1 percent lotion.
- Terbinafine (Lamisil AT) cream or gel.
- Zinc pyrithione soap.
What are the names of the azole antifungal agents?
The azole antifungal agents in clinical use contain either two or three nitrogens in the azole ring and are thereby classified as imidazoles (e.g., ketoconazole and miconazole, clotrimazole) or triazoles (e.g., itraconazole and fluconazole), respectively.
What kind of infections can azole be used for?
Azole antifungal agents can be used to treat fungal infections of the body and skin, including athlete’s foot, onychomycosis (fungal nail infections), ringworm, and vaginal candidiasis.
What is the mechanism of action of azole antimycotic agents?
Their mechanism of action is inhibition of the fungal synthesis of ergosterol by inhibiting lanosterol 14α-demethylase, a cytochrome P450 enzyme (Kyriakidis et al., 2017 ). The inhibition of this major sterol component disturbs the integrity of the fungal plasma membrane (Boucher et al., 2004 ).
What kind of Medicine has an azole ring?
Azole antifungals are a group of medicines that contain an azole ring and inhibit the growth of a wide range of fungi.